Is Jynarque safe?
JYNARQUE (tolvaptan) can cause serious and potentially fatal liver injury. Acute liver failure requiring liver transplantation has been reported [see WARNINGS AND PRECAUTIONS].
What are the side effects of Jynarque?
Common side effects of Jynarque include:
- thirst,
- increased urination (both in volume and frequency),
- nighttime urination,
- indigestion,
- decreased appetite,
- bloating,
- dry skin,
- rash,
Is Jynarque FDA approved?
(Otsuka) announces that the U.S. Food and Drug Administration (FDA) has approved JYNARQUE™ (tolvaptan) as the first drug treatment available to slow kidney function decline in adults at risk of rapidly progressing autosomal dominant polycystic kidney disease (ADPKD).
What is the half life of Jynarque?
In lactating rats administration of radiolabeled tolvaptan, lacteal radioactivity concentrations reached the highest level at 8 hours after administration and then decreased gradually with time with a half-life of 27.3 hours.
Who needs Jynarque?
For adults who are at risk for rapidly progressing ADPKD, JYNARQUE is the only FDA-approved treatment proven to work over a period of years to slow the decline of kidney function. In a Mayo Clinic ADPKD study that included 538 patients, 2 out of 3 people with ADPKD were at risk for rapid progression.
What is the cost of Jynarque?
The cost for Jynarque oral tablet (45 mg-15 mg) is around $16,793 for a supply of 56, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans. A generic version of Jynarque is available, see tolvaptan prices.
What is REMS program?
A Risk Evaluation and Mitigation Strategy (REMS) is a drug safety program that the U.S. Food and Drug Administration (FDA) can require for certain medications with serious safety concerns to help ensure the benefits of the medication outweigh its risks.
Does tolvaptan cause hyperkalemia?
Tolvaptan may increase the rate of hyperkalemia when it is given with ACE-inhibitors, type II ARBs, and potassium-sparing diuretics.
Who prescribes Jynarque?
Find a REMS-certified Nephrologist Your nephrologist will need to join a safety program to prescribe JYNARQUE® (tolvaptan).
Is tolvaptan expensive?
At a drug cost of $5,760 per month, tolvaptan cost $744,100 per QALY gained compared to standard care.
Is there a generic for Jynarque?
No. There is currently no therapeutically equivalent version of Jynarque available in the United States. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Jynarque. These medications may be counterfeit and potentially unsafe.
Can a dog take an antidepressant pill?
The most common among these are antidepressants, anti-anxiety medications, sleep medications and cholesterol-lowering drugs. While antidepressants are sometimes prescribed for dogs, the doses that humans take can be very toxic to pets, especially if they are smaller animals or they have ingested multiple pills.
What happens if you give your dog Tylenol?
Heart problems, fever, and seizures are possible side effects. Other medications including over-the-counter pain relievers such as Mortin (ibuprofen) and Tylenol (acetaminophen), also present dangers to pets. Ibuprofen may result in stomach issues or kidney problems.
What happens if you give your dog Xanax?
Other mental health medications can also have adverse effects when accidentally ingested by pets: Benzodiazepines, like Klonopin (clonazepam) and Xanax (alprazolam), which are often used to treat anxiety disorders, usually have a sedative effect on humans.